Reply to Hu

Reply to HU et al.: On the interpretation of gasdermin-B expression quantitative trait loci data.

We recently published structural and biochemical studies of gasdermin-B (GSDMB) (1), a protein that regulates the maintenance of the epithelial cell barrier as well as cell proliferation and differentiation processes (2, 3). GSDMB amplification and GSDMB overexpression lead to a poor response to HER2-targeted therapy in HER2-positive breast cancer (4). We showed that GSDMB binds to sulfatide an...

The Authors’ Reply

653-658 Hu LAJP 2767:Hu

A highly sensitive liquid chromatographic mass spectrometric (LC-MS/MS) method for determination of pantoprazole in rat plasma using omeprazole as the internal standard (IS) was developed. Plasma samples were precipitated by acetonitrile and separated on a Zorbax SB-C18 column with gradient profile at a flow of 0.4 mL/min. Detection was carried out by SIM mode on an ion-trap LC-MS/MS system wit...

240-244 Hu LAJP 2701:Hu

A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of cilostazol in rat plasma using one-step protein precipitation was developed. After addition of midazolam as internal standard (IS), protein precipitation by acetonitrile was used as sample preparation. Chromatographic separation was achieved on an SB-C18 (2.1 × 50 mm, 5.0 μm) colu...

1849-1853 Hu LAJP 2606:Hu

A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of ketamine in rabbit plasma using one-step protein precipitation was developed and validated. After addition of methadone as internal standard (IS), protein precipitation by acetonitrile was used as sample preparation. Chromatographically separation was achieved on an SB-C18 (2.1 mm...